Amyotrophic lateral sclerosis mimic syndromes
نویسنده
چکیده
Amyotrophic lateral sclerosis (ALS) misdiagnosis has many broad implications for the patient and the neurologist. Potentially curative treatments exist for certain ALS mimic syndromes, but delay in starting these therapies may have an unfavorable effect on outcome. Hence, it is important to exclude similar conditions. In this review, we discuss some of the important mimics of ALS.
منابع مشابه
Is magnetic resonance imaging a plausible biomarker for upper motor neuron degeneration in amyotrophic lateral sclerosis/primary lateral sclerosis or merely a useful paraclinical tool to exclude mimic syndromes? A critical review of imaging applicability in clinical routine.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the cerebral cortex, brainstem, and spinal cord, brain regions in which conventional magnetic resonance imaging is often uninformative. Although the mean time from symptom onset to diagnosis is estimated to be about one year, the current criteria only prescribe magnetic resonance imaging to ex...
متن کاملThe diagnosis of amyotrophic lateral sclerosis.
The term Amyotrophic lateral sclerosis (ALS) covers a spectrum of neurodegenerative syndromes characterized by progressive degeneration of motor neurons (MNs). Other syndromes related to this spectrum of disorders include Progressive bulbar palsy (PBP), Progressive muscular atrophy (PMA), Primary lateral sclerosis (PLS), Flail arm syndrome (Vulpian-Bernhardt syndrome), Flail leg syndrome, and A...
متن کاملEvaluation of the effectiveness of positive psychology-based interventions on post-traumatic growth, self-compassion and quality of life in patients with amyotrophic lateral sclerosis (ALS)
Introduction: Amyotrophic lateral sclerosis (ALS) is a relatively rare disease that can be associated with various mental, physical and psychological burdens. The aim of this study was to evaluate the effectiveness of interventions based on positive psychology on post-traumatic growth, self-compassion and quality of life in patients with amyotrophic lateral sclerosis. Methods: This descriptive-...
متن کاملThe electrophysiology of the motor neuron diseases.
The motor neuron diseases are a set of disorders associated with the selective degeneration of motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common and confers the gravest prognosis. Although ALS occurs with known genetic causes in a small minority, other motor neuron disorders have well-defined genetic mutations. Electrodiagnostic testing is important to distinguish these vari...
متن کاملPathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.
Transactive response DNA-binding protein 43 ubiquitinated inclusions are a hallmark of amyotrophic lateral sclerosis and of frontotemporal lobar degeneration with ubiquitin-positive inclusions. Yet, mutations in TARDBP, the gene encoding these inclusions are associated with only 3% of sporadic and familial amyotrophic lateral sclerosis. Recent transgenic mouse studies have revealed a high degre...
متن کامل